Wikipedia's article (http://en.wikipedia.org/wiki/Calorie_restriction) links to the more-or-less current state of research: Near as I can tell, it's fairly well established that it works, but nobody's completely pegged down the mechanism yet.
OTOH, Walford (Yeah, the walking skeleton on the Biosphere 2 crew.), one of the major proponents of CR (http://isbn.nu/aisbn/walford%20roy%20l) died of "complications of ALS, a rare muscle wasting disease with no well-established modifiable risk factors"(Here) (http://www.imminst.org/forum/index.php?s=&act=ST&f=1&t=3545).
I tried Walford's diet from the 120 year diet out for a few months: IMO, the recipes were expensive, complex, and the food was bland. I am normally NOT very picky about food, but I really couldn't stay on this.
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Date: 2006-10-25 05:44 pm (UTC)OTOH, Walford (Yeah, the walking skeleton on the Biosphere 2 crew.), one of the major proponents of CR (http://isbn.nu/aisbn/walford%20roy%20l) died of "complications of ALS, a rare muscle wasting disease with no well-established modifiable risk factors"(Here) (http://www.imminst.org/forum/index.php?s=&act=ST&f=1&t=3545).
I tried Walford's diet from the 120 year diet out for a few months: IMO, the recipes were expensive, complex, and the food was bland. I am normally NOT very picky about food, but I really couldn't stay on this.